Areas of Research
Our laboratory on the campus of the Washington University School of Medicine participates in grant-funded research while also providing
SNP genotyping and
bioinformatics to other groups.
We have received a one-year, $54,913 grant from the Midwest Forensics Resource Center (MFRC) to research
testing DNA samples for population of origin using single nucleotide polymorphisms (SNPs).
We are currently funded to construct a high-density genetic map and associated resources to support Caenorhabditis briggsae
as a model organism. The results of SNP discovery, assay development, and genetic mapping are freely available to the research community.
In collaboration with Pui Kwok's group at UCSF, we served as a major genotyping center for Phase I of the HapMap Project,
an international effort to construct a high-resolution
haplotype map of the human genome. Our assigned region was chromosome 7p, which included the
Hox-A ENCODE region.
We have developed and continue to refine algorithms for high-throughput assay design. In 2005, we designed FP-TDI genotyping assays for over 6 million
human SNPs for PerkinElmer. We have also assembled a pipeline that designs primers for targeted resequencing of genomic DNA.
Recent Publications
Other Papers on SNP Research
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