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Single nucleotide polymorphisms (SNPs) are important tools for genetic research in humans and other organisms.
Our laboratory, headed by Dr. Raymond Miller, is part of the Washington University School of Medicine. We have characterized hundreds of thousands
of SNPs in humans and model organisms.
Our laboratory served as a major genotyping center in Phase I of the
International HapMap Project.
In collaboration with Dr. Pui Kwok's group at UCSF, we generated over one million genotypes
on human chromosome 7p using the flexible FP-TDI genotyping platform.
Allele frequencies from the HapMap are part of the
SNPseek
database, a compilation of genetic variation and genome annotation data for human SNPs.
We were awarded funding from the Midwest Forensics Resource Center (MFRC) to develop a new tool for
SNP-based DNA forensics.
We are also funded by NIH to construct a high density genetic map along with other forward genetics resources for model organism
C. briggsae.
Please visit our research blog page.
Core Services: SNP Genotyping with FP-TDI
We offer core services in SNP genotyping to the research
community. Our high throughput
FP-TDI platform offers the flexibility to genotype as few as 4 SNPs in 96 samples at a reasonable
cost.
A comprehensive, up-to-date database built from a variety of public sources is maintained in-house to assist us in
SNP selection, assay design, and analysis.
Take a brief tour of our
genotyping demonstration for the actin alpha-2 gene.
Genetic Association Studies and Bioinformatics
Do you need a collaborator for genetic analysis? We can assist you in the planning, sample validation, SNP selection, genotyping, analysis, and publication of your
association study.
We also offer bio-informatics support in the areas of SNP selection,
assay design, targeted resequencing, and SNP discovery.
Please contact us to learn more.
Last updated August 3, 2007.
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