| Authors: Samuel L. Stanley, Jr., Sharon E. Frey, Patricia Taillon-Miller, Jianhua Guo, Raymond D. Miller, Daniel C. Koboldt, Michael Elashoff, Ryan Christensen, Nancy L. Saccone, and Robert B. Belshe |
| Published: July 2007 in Journal of Infectious Diseases Abstract Full Text PDF |
| Abstract: We hypothesized that individuals who develop fever after smallpox vaccination have genetically determined differences in their immune responses to vaccinia virus. We looked for an association between the development of fever and single-nucleotide polymorphisms (SNPs) in 19 candidate genes in 346 individuals previously assessed for clinical responses to smallpox vaccination. Fever after smallpox vaccination is associated with specific haplotypes in the interleukin (IL)–1 gene complex and in the IL18 gene. A haplotype in the IL4 gene was highly significant for reduced susceptibility to the development of fever after vaccination among vaccinia-naive individuals. Our results indicate that certain haplotypes in the IL-1 gene complex and in IL18 and IL4 predict an altered likelihood of the development of fever after smallpox vaccination. Our findings also raise the possibility that these same haplotypes may identify individuals at risk for the development of fever after receipt of other live virus vaccines, providing information that could be useful in anticipating and preventing more-serious adverse events. |
| Supplemental Figure 1 | Results of targeted resequencing in the IL1A gene. | HTML PDF |
| Supplemental Table 1 | Summary analysis of SNP genotyping in 19 candidate genes. | XLS |
| Supplemental Table 2 | Assays used for FP-TDI genotyping. | XLS |
| Sample Information | Gender, race, ethnicity, and AVS status for sample ID's. | XLS |
| Supplemental Data | Raw data from SNP genotyping in 19 candidate genes. | XLS (cases) XLS (controls) |