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Single nucleotide polymorphisms (SNPs) are important tools for genetic research in humans and other organisms.
Our laboratory, headed by Dr. Raymond Miller, is part of the Washington University School of Medicine. We have characterized hundreds of thousands
of SNPs in humans and model organisms.
Our laboratory served as a major genotyping center in Phase I of the
International HapMap Project.
In collaboration with Dr. Pui Kwok's group at UCSF, we generated over one million genotypes
on human chromosome 7p using the flexible FP-TDI genotyping platform.
Allele frequencies from the HapMap are part of the
SNPseek
database, a compilation of genetic variation and genome annotation data for human SNPs.
We were awarded funding from the Midwest Forensics Resource Center (MFRC) to develop a new tool for
SNP-based DNA forensics.
We are also funded by NIH to construct a high density genetic map along with other forward genetics resources for model organism
C. briggsae.
Please visit our research blog page.
Bio-informatics Research
We have developed a number of bioinformatic pipelines in the areas of SNP selection,
assay design, targeted resequencing, and SNP discovery.
To learn more about some of the tools we use in our research, take a look at our
SNP software and databases
section.
Last updated May 29, 2008.
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